1245: Hemodynamic Signature of Pediatric Septic Acute Kidney Injury
نویسندگان
چکیده
منابع مشابه
Septic acute kidney injury: hemodynamic syndrome, inflammatory disorder, or both?
Septic acute kidney injury (S-AKI) is the most common cause of kidney injury in the ICU. Decreased renal blood flow and inflammation have both been suggested as mechanisms of S-AKI. Benes and colleagues present a study of S-AKI in which sepsis is induced by fecal peritonitis and bacterial infusion. In this study, although decreased renal blood flow and increased renal vascular resistance were p...
متن کاملHemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury.
Sepsis is a leading cause of acute kidney injury (AKI) and mortality in children. Understanding the development of pediatric sepsis and its effects on the kidney are critical in uncovering new therapies. The goal of this study was to characterize the development of sepsis-induced AKI in the clinically relevant cecal ligation and puncture (CLP) model of peritonitis in rat pups 17-18 days old. CL...
متن کاملNew developments in septic acute kidney injury.
The kidney is a common "victim organ" of various insults in critically ill patients. Sepsis and septic shock are the dominant causes of acute kidney injury, accounting for nearly 50 % of episodes of acute renal failure. Despite our substantial progress in the understanding of mechanisms involved in septic acute kidney injury there is still a huge pool of questions preclusive of the development ...
متن کاملEpithelial transport during septic acute kidney injury.
A goal for scientists studying septic acute kidney injury (AKI) should be to formulate a conceptual model of disease that is able to coherently reconcile the molecular and inflammatory consequences of sepsis with impaired epithelial tubular function, diminished glomerular filtration rate (GFR) and ultimately kidney failure. Recent evidence has shed light on how sepsis modulates the tubular regu...
متن کاملHemodynamic and metabolic alterations associated with septic acute kidney injury in experimental sepsis
Methods 12 animals were randomized to sepsis (n = 8) or sham procedure (n = 4). A pre-calibrated flow probe was positioned around the renal artery to measure renal blood flow (RBF) and a catheter was inserted into the renal vein to measure renal vein oxygen content and calculate renal oxygen consumption, corrected for body surface area (renal VO2I). A tissue oxygen-tension electrode and a micro...
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ژورنال
عنوان ژورنال: Critical Care Medicine
سال: 2020
ISSN: 0090-3493
DOI: 10.1097/01.ccm.0000730868.33184.4c